Document Type
Restricted
Advisor
Timo Ovaska
Publication Date
2019
Abstract
The frondosin family of compounds was first discovered in 1997 in the marine sponge Dysidea Frondosa and later determined to exhibit anti-inflammatory, anti-tumor and HIV- inhibitory activities. This study discusses two different approaches for the synthesis of the tetracyclic structure of frondosin D. The main intermediate in both pathways is a 7-membered ring tricyclic compound, accessed via tandem 5-exo dig cyclization/Claisen rearrangement methodology developed previously by the Ovaska group.
Recommended Citation
Chu, Duc, "Progress toward the Total Synthesis of Frondosin D" (2019). Chemistry Honors Papers. 26.
https://digitalcommons.conncoll.edu/chemhp/26
The views expressed in this paper are solely those of the author.