The frondosin family of compounds was first discovered in 1997 in the marine sponge Dysidea Frondosa and later determined to exhibit anti-inflammatory, anti-tumor and HIV- inhibitory activities. This study discusses two different approaches for the synthesis of the tetracyclic structure of frondosin D. The main intermediate in both pathways is a 7-membered ring tricyclic compound, accessed via tandem 5-exo dig cyclization/Claisen rearrangement methodology developed previously by the Ovaska group.
Chu, Duc, "Progress toward the Total Synthesis of Frondosin D" (2019). Chemistry Honors Papers. 26.
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