Document Type

Article

Domestic/International

Domestic

Location

Cambridge, MA

Publication Date

2025

Abstract

In nearly all organisms, primordial germ cells (PGCs) must make a successful migration from their point of specification to their niche to form the gonads. They may not always make a successful migration, and failure may lead to defects in the organism. For example, in humans, this may lead to gonadal dysgenisis and teratomas. Germplasm is a substance utilized at the point of specification of PGCs to repress cells from becoming somatic, and we know that a higher germplasm content has been shown to improve chances of PGC migration success. We do not understand how germplasm does this, and this project aims to dissect how exactly it controls factors of PGC migration success.

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The views expressed in this paper are solely those of the author.